Neil S. Forbes, Robert S. Coffin, Liang Deng, Laura Evgin, Steve Fiering, Matthew Giacalone, Claudia Gravekamp, James L. Gulley, Hal Gunn, Robert M. Hoffman, Balveen Kaur, Ke Liu, Herbert Kim Lyerly, Ariel E. Marciscano, Eddie Moradian, Sheryl Ruppel, Daniel A. Saltzman, Peter J. Tattersall, Steve Thorne, Richard G. Vile, Halle Huihong Zhang, Shibin Zhou and Grant McFadden
Journal for ImmunoTherapy of Cancer, 6:78 (6 August 2018)
"This White Paper is designed to increase the interactions between these growing fields [oncolytic virotherapy and bacterial therapy of microbial oncolytics], and introduce their advances to the wider community of scientists and clinicians working on immunotherapies for cancer. We also describe the state of the field of microbial cancer therapy and point the direction where development and greater synergies with other fields are needed to increase the number of patients and indications that could benefit from this powerful modality."
Robert J. Canter and William J. Murphy
Journal for ImmunoTherapy of Cancer, 6:79 (7 August 2018)
"With only a 25% response rate in patients treated with immunotherapy, researchers are looking to further explore the role of natural killer (NK) cells in cancer immunotherapy. Robert J. Canter and William J. Murphy comment on studies highlighting the potential efficacy and hurdles of utilizing NK cells to overcome immune resistance through novel mechanisms in which NK cells are able to seek out and respond to tumors. The authors discuss the strong biological role of NK cells in tumor immunology as well as critical issues which arise during in vivo validation of human NK cell effects observed in vitro due to the differences between mouse and human NK cells."
Mark R. Albertini
Journal for ImmunoTherapy of Cancer, 6:80 (22 August 2018)
From the Authors
"The February 1, 2018 Journal of Clinical Oncology article "Nivolumab Plus Ipilimumab in Patients With Advanced Melanoma: Updated Survival, Response, and Safety Data in a Phase I Dose-Escalation Study" by Callahan et al reports a 3-year overall survival rate of 63% for 94 patients with previously treated or untreated advanced melanoma who received ipilimumab and nivolumab as concurrent therapy. That accomplishment is a major one in our field and demonstrates the progress made via evidence-based understanding of cause and effect related to the immunotherapy of human melanoma. This commentary provides an historical perspective for the greatly improved overall survival with immunotherapy for metastatic melanoma patients, discusses the transition from the dark ages to the age of enlightenment in melanoma immunotherapy, and provides a roadmap for a better tomorrow for patients with metastatic melanoma."
Mark R. Albertini, MD — University of Wisconsin Carbone Cancer Center
Nolan A. Wages, Cody Chiuzan and Katherine S. Panageas
Journal for ImmunoTherapy of Cancer, 6:81 (22 August 2018)
Clinical Trials Monitor
From the Authors
"In early-phase clinical trials, the classic assumptions imposed by cytotoxic agents may no longer be applicable to immune-oncology agents, requiring new strategies for dose selection and trial design. The main goal of this article is to summarize and highlight main challenges of early-phase study design of immunotherapies from a statistical perspective. Further advances in the effectiveness of cancer immunotherapies will require new approaches that include redefining the optimal dose to be carried forward in later phases, incorporating additional endpoints in the dose selection process, developing personalized biomarker profiles, or testing drug combination therapies to improve efficacy and reduce toxicity."
Nolan A. Wages, PhD — University of Virginia
Won Jin Ho, Mark Yarchoan, Alex Hopkins, Ranee Mehra, Stuart Grossman and Hyunseok Kang
Journal for ImmunoTherapy of Cancer, 6:84 (31 August 2018)
From the Authors
"In our single-institution retrospective study, baseline lymphopenia was significantly associated with poorer response to PD1 inhibitor therapy in patients with metastatic head and neck cancer. This is particularly important since a substantial proportion of patients with head and neck cancers develop persistent treatment-related lymphopenia while undergoing first-line concurrent chemoradiotherapy. Further work is warranted to confirm the utility of baseline lymphocyte count as a predictive biomarker of checkpoint immunotherapy in a prospective setting."
Hyunseok Kang, MD, MPH — University of California, San Francisco
Christine A. Garcia, Alex El-Ali, Tanya J. Rath, Lydia C. Contis, Vikram Gorantla, Jan Drappatz and Diwakar Davar
Journal for ImmunoTherapy of Cancer, 6:83 (31 August 2018)
"Although PD-1 and CTLA-4 inhibitors are widely known to induce immune-related adverse events (irAEs) in patients, neurologic-specific irAEs are not well characterized. Christine A. Garcia et al. presents a case report detailing two melanoma patients treated with ipilimumab in the adjuvant setting who subsequently developed ipilimumab-related neurologic irAEs. This report highlights the importance of early symptom recognition followed by proper diagnostic evaluation in order to identify unusual neurologic irAEs and promptly initiate immunosuppressive therapy for reversal of neurological effects."
Jacob Appelbaum, David Wells, Joseph B. Hiatt, Gideon Steinbach, F. Marc Stewart, Hannah Thomas, Paul Nghiem, Raj P. Kapur, John A. Thompson and Shailender Bhatia
Journal for ImmunoTherapy of Cancer, 6:82 (31 August 2018)
"Immunotherapy with ICIs improves cancer outcomes, but can be associated with varied side effects. In the case above, a single dose of nivolumab plus ipilimumab led to complete eradication of a patient’s widely metastatic MCC [merkel cell carcinoma], but unfortunately was complicated by rapid and irreversible destruction of the patient’s myenteric ganglions that ultimately proved fatal. The case described above illustrates both the promises and pitfalls of the power of immune checkpoint blockade."
Guacimara Ortega Sanchez, Kathleen Jahn, Spasenija Savic, Alfred Zippelius and Heinz Läubli
Journal for ImmunoTherapy of Cancer, 6:85 (3 September 2018)
From the Authors
"Immune checkpoint inhibitors lead to pulmonary immune-related adverse events in a minority of treated patients. However, acute and chronic late-onset pneumonitis are severe side effects and algorithms for the initial treatment with corticosteroids have been well established, but the treatment of patients with corticosteroid-refractory or -dependent pneumonitis is less clear. Here, we describe the successful treatment with infliximab of a patient with a chronic late-onset pneumonitis due to PD-1 blockade that was corticosteroid-dependent and mycophenolate-resistant. This case report demonstrates how difficult-to-treat pulmonary patients could be managed and infliximab might be preferable in such situations."
Heinz Läubli, MD, PhD — University Hospital Basel
Orneala Bakos, Christine Lawson, Samuel Rouleau and Lee-Hwa Tai
Journal for ImmunoTherapy of Cancer, 6:86 (3 September 2018)
From the Authors
"Nearly all patients with solid tumors receive standard-of-care surgical resection of their primary tumor because it represents their best chance for cure. Despite complete resection, many patients recur or develop metastases and ultimately die of disease. Existing and emerging immunotherapies are ideally suited to target minimal residual disease such as in the postoperative period where tumor burden is at its lowest. In this review, we highlight the importance of rationally combining surgery and immunotherapy to reduce postoperative recurrence and metastases."
Lee-Hwa Tai, PhD — Universite de Sherbrooke
Fathia Mami-Chouaib, Charlotte Blanc, Stéphanie Corgnac, Sophie Hans, Ines Malenica, Clémence Granier, Isabelle Tihy and Eric Tartour
Journal for ImmunoTherapy of Cancer, 6:87 (4 September 2018)
From the Authors
"This review focuses on the emerging role of resident memory T (TRM) cells in anti-tumor immune responses and their ability to remain permanently in the tumor microenvironment and to specifically recognize and kill malignant cells. TRM cells are enriched with tumor-specific T cells explaining their good prognostic value in cancer patients. The ability to target and expand this T-cell population may be associated with clinical response to immunotherapy."
Fathia Mami-Chouaib, PhD — Inserm
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