Arlene Sharpe, MD, PhD is the Kolokotrones University Professor, Harvard University and Chair, Department of Immunology, Harvard Medical School (HMS). She is a member of the Department of Pathology at Brigham & Women’s Hospital (BWH) and the Broad Institute of MIT and Harvard, and Leader of the Cancer Immunology Program at the Dana-Farber/Harvard Cancer Center. Dr. Sharpe earned her MD and PhD degrees from HMS and completed her residency in Pathology at BWH. She is a leader in the field of T cell costimulation. Her laboratory has discovered and elucidated the functions of T cell costimulatory and coinhibitory pathways, including the immunoinhibitory functions of the CTLA-4 and PD-1 pathways. Her laboratory currently focuses on elucidating roles of these pathways in regulating effective anti-tumor immunity and tolerance, and translating this fundamental understanding into new therapies. She is member of the National Academy of Sciences and National Academy of Medicine, and a Fellow of the American Association for Cancer Research, National Academy of Inventors, the Society for Immunotherapy of Cancer, and the American Association of Immunologists. She received awards including the William B. Coley Award, the SITC Richard V. Smalley Memorial Award and Lectureship, the FASEB Excellence in Science Lifetime Achievement Award, the AAI Lifetime Achievement Award, and the American Society for Investigative Pathology Rous-Whipple Award.