SU2C-SITC Convergence Scholar Award 1

SU2C Convergence Research Team: Single-Cell Functional Multi-omics to Characterize and Monitor CAR-T

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Team Leader

Rong Fan, PhD – Yale University

Team Members

Stephanie Halene, MD, PhD
Yale School of Medicine and Yale University
Carl H. June, MD
University of Pennsylvania Perelman School of Medicine
Pablo G. Cámara, PhD
University of Pennsylvania Perelman School of Medicine
J. Joseph (“Jos”) Melenhorst
University of Pennsylvania Perelman School of Medicine

Project Summary

Immunotoxicity and autoimmune-like response is a significant problem hindering widespread use of cancer immunotherapies. Major players in the immune response are cytokines, which are substances secreted by some immune cells to affect other cells in response to a signal, e.g., recognition of a foreign body. To understand this response, the full spectrum of cytokine functions in a pre-infusion setting will be assessed and matched with patient responses to treatment with the chimeric antigen receptor (CAR) T therapy. Afterward, the function of the infused CAR T cells will be assessed to determine the mechanisms of efficacy and/or immune toxicity. The team also proposes identifying molecular characteristics underlying therapeutic efficacy and toxicity of CAR T therapy, and biomarker discovery by using computational models and machine learning that look at the data. If successful, this will create a “tool” that clinicians can use to mitigate patient risk associated with CAR T therapies while improving the chances of therapeutic success.

Apply Now

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Applications due: Sept. 28, 2018


Details vary by project and institution, but the following applies to each opportunity
  • Full-time, multi-year commitment
  • Salary commensurate with experience and applicable policies
  • Fellowship will take place at either the Team Lead's institution or a partner institution
  • Additional eligibility criteria are determined by the Team Leads and host institutions