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Recovery from secondary adrenal insufficiency in a patient with immune checkpoint inhibitor therapy induced hypophysitis 

09-13-2019 13:09

Hypophysitis is a well-recognized immune-related adverse event in patients treated with immune checkpoint inhibitors for cancer. Some anterior pituitary hormones may recover; however, secondary adrenal insufficiency is usually permanent. This case documents an unusual recovery from secondary adrenal insufficiency in a patient who developed hypophysitis from immune checkpoint inhibitor therapy. Repeated pituitary hormone testing every three months for the first year after the development of hypophysitis may identify more patients with hypothalamic-pituitary-adrenal axis recovery.

Authors: Sahityasri Thapi, Amanda Leiter, Matthew Galsky and Emily J. Gallagher

Published as a case report in the Journal for ImmunoTherapy of Cancer (2019) 7:248.

#ImmuneResponsiveness#RenalCellCarcinoma#CombinationTherapy
#Ipilimumab#Nivolumab#AdverseEvents#SideEffects#Toxicities#JournalArticle
#JournalforImmunoTherapyofCancer#Clinician#Oncologist#Pharmacist
#Researcher#2019

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