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Posted 5/13/2019The inaugural Chair will provide strategic leadership and direction for all aspects of the department working closely across the College, Cancer Center, and the clinical partner Dignity Health/ St. Joseph's Hospital and Medical Center. The Chair will be responsible for all planning, policy, operations and oversight of academic and research programs of the department. The Chair will have financial authority over the state-appropriated budget assigned to the department, extramural research funding received and funding generated through the Cancer Program Affiliation Agreement, in collaboration with Cancer Center leadership, and other financial matters for the department in accordance with applicable University and College policies and practices. The Chair will engage department division chiefs and will enhance the academic quality of fellowship, undergraduate and graduate medical education programs. Duties & Responsibilities- Provide leadership and management of day-to-day operations of the Department of Interdisciplinary Oncology as well as:- Faculty Affairs- Educational and training programs- Research programs- Patient care programs- Integrate basic and translational cancer research into the UACC operations in Phoenix.- Finances and budget- Diversity and inclusion
Minimum Qualifications Qualified candidates must possess a doctoral degree (PhD, MD, or equivalent) from an accredited institution and be eligible for a University of Arizona academic appointment at the Associate or Full Professor level. A record of administrative experience in an academic medical center setting. A demonstrated ability to grow revenues, meet budgets, measure and improve productivity and outcomes, and under take appropriate business strategies to achieve division, unit department and/or enterprise goals. Experience in the development and successful implementation of new academic programs and services, as well as program review and assessment. For a full description and to apply, visit http://uacareers.com/postings/35548 At the University of Arizona, we value our inclusive climate because we know that diversity in experiences and perspectives is vital to advancing innovation, critical thinking, solving complex problems, and creating an inclusive academic community. We translate these values into action by seeking individuals who have experience and expertise working with diverse students, colleagues and constituencies. Because we seek a workforce with a wide range of perspectives and experiences, we encourage diverse candidates to apply, including people of color, women, veterans, and individuals with disabilities. As an Employer of National Service, we also welcome alumni of AmeriCorps, Peace Corps, and other national service programs and others who will help us advance our Inclusive Excellence initiative aimed at creating a university that values student, staff, and faculty engagement in addressing issues of diversity and inclusiveness.Apply Here: http://www.Click2Apply.net/vjzmn5jxmgq4ccn6
Posted 5/10/2019The Kellogg Cancer Center and Division of Hematology and Oncology at NorthShore University HealthSystem (NorthShore), the principal teaching affiliate of the University of Chicago Pritzker School of Medicine, seeks an exceptional physician with extensive clinical experience ideally in lung cancer and expertise in immunotherapy to oversee the implementation of existing and novel clinical programs, clinical and translational research, and other key elements including clinical laboratory aspects, pharmacy integration, education and outreach internally and externally with additional goal of laying the groundwork for implementation of programs outside of cancer. Within lung cancer, the director will oversee lung cancer research including clinical trials development and implementation, and translational research utilizing our extensive biorepository, annotated database and structured clinical documentation notes. This physician will collaborate with programs within molecular pathology, personalized medicine, the NorthShore Research Institute and with programs including the Genomic Health Initiative. The successful candidate will have a minimum of five years’ experience leading and/or developing aspects of an immunotherapy and lung cancer research program; an understanding of key aspects to successfully with pathology to implement appropriate clinical laboratory assays and with a background or clear knowledge of key aspects of translational research. Prior experience and success in obtaining external funding and comfort in seeking pharmaceutical industry relationships for clinical research in immunotherapy and lung cancer is preferred. Excellent communication, interpersonal skills also required and previous leadership experience is a plus. Applicants must be board certified in Medical Oncology.This is an excellent opportunity to provide quality patient care within a highly successful, expanding organization. NorthShore Medical Group is a physician-led, multi-specialty group with over 980 physicians and growing. NorthShore is a comprehensive, fully integrated, healthcare delivery system that includes four hospitals - Evanston Hospital, Glenbrook Hospital, Highland Park Hospital, and Skokie Hospital. NorthShore is a member of the Mayo Clinic Care Network; Mayo’s only collaboration of its kind in the Chicago region. NorthShore offers a state-of-the art EMR and ranks as one of the “Most Wired” hospital systems by Hospital and Health Networks. NorthShore is committed to excellence in its academic mission and supports teaching and research. Academic appointment to the University of Chicago is available and expected for qualified candidates. We offer a competitive salary and comprehensive benefit package.Qualified candidates may submit a CV and cover letter to: Dr. Bruce Brockstein, Division Head of Hematology and Oncology, Medical Director, Kellogg Cancer Center by contacting: Michelle Forray, Physician Recruiter, email@example.com (847) 982-4802Affirmative Action/Equal Opportunity Employer. NorthShore is committed to hiring a diverse workforce
Posted 4/25/2019We are interested in candidates who wish to uncover: 1) key mechanisms regulating cancer-associated adaptiveand innate immune cells in the tumor microenvironment and identify new immune-oncology therapies, including T cell and B cell repertoire analysis, single cell and deconvolution analysis of myeloid complexity and functional status, and computational modeling of tumor/stromal interactions; and 2) understand the consequences of tumor heterogeneity for tumor evolution, treatment, and outcome, where aspects of tumor biology might be interrogated by computational analysis and integration of data generated from a variety of techniques, include imaging, DNA sequence characterization, and measurements of mRNA or protein.We seek faculty members with a strong commitment to interdisciplinary collaboration, integrated team science and open science. Candidates should have advanced training in machine learning or statistical learning techniques, with a track record of innovation in a biomedical and/or clinical application, as evidenced by a strong publication record and development of novel methodological approaches.Successful candidates will be a member of the Knight Cancer Institute Computational Biology program and hold appropriate appointments in the department of Cell, Developmental & Cancer Biology (CDCB) and either the Division of Bioinformatics and Computational Biology (BCB) in the Department of Medical Informatics and Clinical Epidemiology or the Department of Biomedical Engineering (BME) based on candidate’s interests and research.Applicants should have a Ph.D. in computer science, applied mathematics/statistics, computational biology, or relevant quantitative scientific discipline. Applications should include a CV, research plan, and cover letter, which may be up to 4 pages. We encourage including the following in the cover letter: 1) links to relevant methodology and associated open source code (e.g. through GitHub or other code repository) that you view as most impactful and describe the relevance to advancing one of the research areas listed in item 3 below; 2) Describe how your personal philosophy or career goals relate to the values of interdisciplinary collaboration and team-science, with specific examples of how you have embodied these values in your career to date; and 3) Indicate your research interests with regards to translational cancer biology specifically pertaining to tumor-host interactions, cancer microenvironment, or cancer immunobiology.We offer highly competitive recruitment packages, strong institutional commitments to faculty support, comprehensive benefits, relocation services, and a rewarding work and life environment. We seek candidates who embrace and reflect diversity in the broadest sense. OHSU is an equal opportunity / affirmative action employer Minorities/ Women/ Individuals with disabilities/ Protected Veterans are encouraged to apply. OHSU is ranked as one of the nation’s top biomedical institutions in patient care, research, and education, with an annual operating budget of over $2.3 billion, over $340 million in annual grant funding, over 4,000 students and trainees, and nearly 1 million patient visits per year. OHSU provides substantial resources to enable leading computational research, including a world-class exascale supercomputing cluster, close interactions with leading technology companies, tight integration with clinical and basic research programs across campus, graduate training programs in computational biomedicine, bioinformatics, biostatistics, biomedical informatics, and biomedical engineering, and substantial long-term resource commitments.Review of applications will begin immediately and will remain open until positions are filled.To apply visit: https://www.ohsu.edu/human-resources and refer to posting #IRC79634 and #IRC54682
Laboratories within the Knight Cancer Institute at Oregon Health & Science University in beautiful Portland, OR have multiple openings for postdoctoral fellows. Visit http://www.ohsu.edu/cdcb-postdoc for links to laboratories with openings. Please apply directly to laboratory principal investigators via email.Sud Anand, PhD: Research projects on non-coding RNAs in host cells impacting solid tumor progression with emphasis on immune cells in the tumor microenvironment.Lisa M Coussens, PhD: We are broadly interested in understanding signals controlling innate and adaptive leukocyte responses and activities in solid tumors with projects examining myeloid - T cell cross talk and mechanisms regulated by complement proteins as mediators of tumor progression and tumor immunity.Alexey Danilov, M.D., PhD: Preclinical and translational research on elucidating novel targets within the ubiquitin-proteasome pathway and mechanism of action and resistance to transcriptional CDKs in B-cell malignancies.Lara E. Davis, MD: Translational sarcoma research elucidating aspects of the osteosarcoma immune microenvironment and undefined kinase fusions and optimizing CDK4 inhibition to increase sarcoma sensitivity to chemotherapy.Julia Maxson, PhD: Understanding how genetic alterations cooperate to drive leukemia, and leveraging that information to develop therapeutic strategies.Gordon Mills, MD, PhD: Translational programs characterizing mechanisms of drug sensitivity and resistance in human tumors with broad array of wet bench and bioinformatics tools.Amy Moran, PhD: Translational cancer immunotherapy projects evaluating cross talk between sex steroids and immune cell function, role of microbiome, and mechanisms of action of non-conventional of T & NK cell inhibitors.Ferdinando Pucci, PhD: Humoral immune responses, cell-mediated immunity, and antigen-specific immune reactions to tumor-derived extracellular vesicles impacting malignancy with the goal of developing next generation cancer vaccines.Rosalie Sears, PhD: Pancreatic cancer research projects focused on tumor heterogeneity, lineage plasticity, epigenetic regulation and mechanisms of therapeutic resistance using omic and image analysis of patient tumors, patient-derived and genetic mouse models.Josh Walker, M.D., PhD: Tumor cell intrinsic and microenvironmental factors regulating T cell effector dysfunction in cancer, impacting efficacy of novel combinations of chemotherapy, radiotherapy, and immunotherapy in cancer utilizing preclinical models with defined tumor antigens and clinical samples.
Posted 4/25/2019Heal the sick, Advance the science, Share the knowledge.The successful candidate will be an immunologist with expertise in senescent remodeling of the immune system with aging and will lead an independent and nationally and internationally-recognized research program. This person will hold academic rank at Mayo Clinic commensurate with experience and qualifications. The ideal candidate will target the profound changes that occur in the immune system with age and how such changes can be linked with the progression of a variety of chronic illnesses and increased risk of acute infections, using cutting edge technologies. Specific areas of interest may include effects of age on micro- environmental niches supporting adaptive immune cell development, cell intrinsic physiologic changes in long-lived adaptive immune cells, age-related extrinsic stresses impacting immune cells and the aging of the innate immune system. Faculty will be expected to work collaboratively with colleagues and to be an active participant in the enterprise-wide Department of Immunology and the Robert and Arlene Kogod Center on Aging. The individual may also align with other Mayo Clinic centers such as cancer, transplant, cardiovascular diseases, biomedical discovery, individualized medicine and regenerative medicine.Qualifications Credentials of a successful candidate will include a doctoral degree (PhD, MD/PhD, MD or equivalent) in a biomedical science field and rigorous postdoctoral training. Junior investigators should have a strong publication record; evidence of successful competition for external funding is preferred. Mid-career investigators must have a strong publication record and history of NIH- or equivalent extramural funding.MAYO CLINIC is an integrated, multidisciplinary academic medical center with comprehensive programs in medical education and research that span across three group practice and research sites. We support a vibrant and diverse research enterprise, with programs in basic, translational, clinical, and population sciences. Mayo has world-class faculty, laboratories, and state-of-the-art core facilities and biorepositories. The Mayo Clinic Graduate School of Biomedical Sciences trains and supports PhD and MD/PhD students.We offer a highly competitive compensation package with sustained salary support, capital equipment funding, technical and computational resources, and exceptional benefits. Mayo Foundation is an affirmative action and equal opportunity educator and employer that values and promotes diversity as a strategic advantage.Mayo Clinic's campuses in Arizona are located in Phoenix and Scottsdale, in the beautiful Sonoran Desert. With Phoenix being the sixth largest city in the nation, this sunny "desert metropolis" offers the amenities of a big city in the midst of a strikingly beautiful, rugged, southwest landscape.Scottsdale frequently earns praise as a highly desirable place to live. The city's more than 200,000 residents enjoy a vibrant mix of culinary hot spots, arts and entertainment, professional and collegiate sports teams, and community resources. The region's desert climate promotes an outdoor lifestyle with a full complement of sports and recreation.Click here to learn more and apply! Applications should include a cover letter, CV and a statement of r esearch interests. Specific questions should be directed to: Dr. Sandra Gendler, Ph.D. Department of Immunology Chair, Search Committee C/O Adriana Semko firstname.lastname@example.org©2019 Mayo Foundation for Medical Education and Research. Post offer/pre-employment drug screening is required. Mayo Clinic is an equal opportunity educator and employer (including veterans and persons with disabilities). As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.
Posted 4/19/2019The Technical Director in this key leadership position provides technical expertise, analytical capability, strategic planning and project management support, ensuring the highest quality and safety of all products manufactured or issued through the Novel Cell Therapy Laboratory. The Novel Cell Therapy Laboratory within the Connell O’Reilly Cell Manipulation Core Facility (CMCF) at DFCI is responsible for development of investigational cell-manufacturing procedures and manufactures a variety of cellular products for patients enrolled on clinical research trials at DFCI, BWH, BCH, MGH, BIDMC and other clinical sites, operating under both internal and external IND/IDEs. Examples of these projects include Cancer Vaccines, CAR-T cells, Pluripotent Stem Cells, genetically-engineered stem cells, manipulated BMT products, Mesenchymal Stem Cells, etc. The Director is responsible for managing several leadership positions within NCT, including a manager, supervisors, project leads and processing specialists. In addition, the Director will likely have oversite of company-sponsored staff for the duration of various projects.This position reports into the Laboratory’s Medical Director and the Administrative Director. The Director works closely with senior executives, IND sponsors and key investigators. The Director works closely with the Medical Director on patient care workflows, Associate Business Director to establish budgets for manufacturing of novel products and with Quality Management.Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.Technical Responsibilities
Oversees investigational manufacturing and analysis of all cellular therapy products in the Novel Cell Therapy Laboratory (NCT)
Serves as a key subject matter expert on advanced cell therapy practices, procedures and aseptic techniques.
Works with academic investigators and industry collaborators to develop new clinical-scale cell manufacturing procedures and SOPs for use in clinical research protocols.
Develops, manages and coordinates validation protocols, execution of validation studies, data analysis, and the compilation of the validation data and results into final reports. The summary of these results is often critical in the filing of IND/IDE submissions.
Serves as customer liaison for all sponsored projects involving novel cellular product development and manufacturing. This may entail orchestrating multidisciplinary meetings with sponsors, summarizing data, and constructing action plans and timelines.
Reviews validation results against protocol acceptance criteria and makes modifications as applicable in collaboration with sponsors, investigators and quality assurance staff to meet acceptable release criteria.
Works collaboratively with faculty investigators, quality assurance staff, industry sponsors and regulatory officials to produce information for IND submissions and other FDA filings.
Continually monitors and updates current production methods and laboratory management policies to be consistent with current best practices as reported in the relevant scientific literature
Prepares and submits data for preparation of manuscripts or other scientific presentations
Represents the CMCF in the cellular therapy field, internally and externally through participation in research and leadership activities at the national and international level
In collaboration with the Executive Director and the Assistant Medical Director, communicates with clinical colleagues regarding patient treatmentLaboratory Management
Ensures that NCT staff work under GTP and GMP regulations, providing optimal support, training, review, competencies assessments, productivity and performance excellence.
Working with NCT manager and supervisors to schedule product processing, determine staffing needed based on this schedule
Directs an appropriate number of technical and support staff to meet the operational needs of the department. Recommends staffing adjustments to the CMCF leadership based on project requirements.
Responsible for timely staff performance evaluations using established appraisal tools to assess competence and formulate professional and personal development plans.
Works with CMCF and DFCI administration on developing a retention program based on established career ladder and individual goals of employees. This is accomplished by proactive discussions to understand each employee's needs.
Responsible for in collaboration with Human resources for employee counseling and progressive discipline processes as warranted.Compliance
Ensures compliant operations at all levels and functional areas including technical and scientific conduct, patient and employee safety, financial integrity, human resources management and competencies, quality assurance and ensuring an “inspection ready” laboratory always
Develops a monitoring protocol to ensure compliance with established and approved procedures and minimize practice deviation
Works with NCT Laboratory Manager and Supervisors to keep documents current and ensures at least biannual review of documents.
Collaborates with the NCT leadership team to initiate, review and approve batch records, data and product outcomes.
Works with the Laboratory Manager, Supervisors and QA team to respond to events, propose and initiate corrective action and monitor for compliance with corrective action plan.
Ensures compliance with requirements of all applicable regulatory and accrediting entities including but not limited to FDA, JC, CLIA, CAP, AABB, FACT, CMS, DPH, collaborating closely with quality assurance staff at all timesPlanning and Resource Management
Serves as a member of the executive leadership team for the CMCF
Assists in gathering information about novel projects and accomplishments for each renewal of the DF/HCC comprehensive cancer center support grant, CMCF website and other annual reports such as FDA annual reports
Plays a key role in the development and implementation of strategic and business plans within CMCFFiscal Management
In conjunction with the CMCF leadership develops an operating budget using established accounting principles to maximize revenue and minimize expense.
Monitors monthly revenue and expense activities by analyzing data to meet budget goals, justify variances and make corrective revisions as appropriate.
Evaluates and recommends the acquisition of capital equipment by developing business plans that address growth of current services and/or new opportunities.
Manages equipment and space, construction/renovation, site preparation and installation by planning and coordinating with internal and external parties to complete projects within established timelines and approved budgets.
Manages supply levels by working with materials management to assure supply availability and control costs.Communication
Develops an open and ongoing communication with the department, Institute staff and trial sponsors.
Creates and maintains a learning environment that facilitates development of staff, colleagues and students.
Participates in professional and educational activities to promote self-development and continued learningQualifications
Master’s degree in medical technology or biological science required at a minimum. Doctoral degree in any biological science or medical field highly desirable. Must meet the minimum CLIA requirements for supervisor in a highly complex testing laboratory. Knowledge of flow cytometry, molecular biology, genetic engineering is highly desirable.This position requires 5 or more years of management experience in a cellular therapy lab, related pre-clinical research laboratory, or related experience in biotechnology or pharmaceutical company also acceptable.Must have knowledge of FDA (cGTP and cGMP), AABB, FACT, CLIA, JC, and DPH regulations regarding laboratory procedures.Apply on line:
https://careers-dfci.icims.com/jobs/14644/technical-director-for-novel-cell-therapy-laboratory/jobDana-Farber.org/CareersDana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.
Posted 4/19/2019How have you impacted someone's life today? At Hackensack Meridian Health our teams are focused on changing the lives of our patients by providing the highest level of care each and every day. From our hospitals, rehab centers and occupational health teams to our long-term care centers and at-home care capabilities, our complete spectrum of services will allow you to apply your skills in multiple settings while building your career, all within New Jersey's premier healthcare system.The Hackensack Meridian Health Center for Discovery and Innovation (CDI) is offering a position for postdoctoral research studies in the field of cancer immunotherapy in the laboratory of Dr. Johannes Zakrzewski. The laboratory is part of the CDI's Multiple Myeloma Institute, is aligned with the John Theurer Cancer Center at Hackensack University Medical Center and has close ties to the Lombardi Comprehensive Cancer Center of Georgetown University. The long-term goal of the laboratory's interdisciplinary research program is to develop novel immunotherapeutic and molecular strategies for targeted cancer therapy. The Zakrzewski laboratory focuses on NF-KB as a therapeutic target in immunology and cancer, and on harnessing the thymus and genetic manipulations of hematopoietic progenitor cells for cancer therapy. The research program builds on previous discoveries involving small molecule inhibitors, progenitor cell immunotherapies and manipulations of the thymic microenvironment. The research program incorporates both basic preclinical and translational research and is aimed towards clinical translation of its most promising discoveries. The successful postdoctoral candidate will have a strong interest in cancer immunotherapy and chimeric antigen receptor technology. The candidate will perform in vivo animal models and in vitro analyses. The postdoctoral fellow is expected to understand the project and work independently taking responsibilities in the development and execution of experimental procedures to successfully advance the research project. The successful candidate will be responsible for preparation of data for presentations, progress reports, and the preparation of manuscripts and posters. The post-doctoral fellow is anticipated to have good communication and writing skills. The successful candidate will have a team-oriented mindset and will provide guidance to junior members.Responsibilities
Apply Here: https://careers-hackensackmeridianhealth.icims.com/jobs/54141/pstdc-rsch-fllw%2c-immuno-onc/job
Posted 4/17/2019Lee Moffitt Cancer and Research Institute is a modern facility in Tampa, Florida. We strive to be the leader in understanding in the complexity of cancer through team science and applying those insights for human benefits. Be part of the cure by joining Moffitt's team of over 800 research faculty scientists, career staff scientists, postdocs, graduate students and support staff dedicated to cancer researchThe Cell Therapy Core is recurring for Cell Therapy Technologist I in Tampa, FL.Position Highlights
Opportunity to join a NCI designated comprehensive cancer center in production of novel cellular therapy treatments for cancer patients
Participation in cutting edge-immunotherapy clinical trials designed to activate immune system cells for the treatment of cancer
Develop and perform assays on cellular products for safety and function
Involvement in the rapidly growing multiple clinical trials within the cell therapy area.The Ideal Candidate
Experience in cellular therapy or a related field
Proficient in cell culture and aseptic technique
Working knowledge of adoptive cell therapy and immunotherapy
Understanding of good documentation, laboratory and manufacturing practices and requirements
The successful candidate will be a strong communicator, engaged, and will work closely with members of the Cell Therapy Team.
Exhibit interest and excitement in participating in the production of cellular products
Working knowledge of quality control assays including ELISA, qPCR, flow cytometry and cell counting techniques
Willingness to work flexible hours, including periodic weekendsResponsibilities
Working with minimal supervision, perform cellular product processing using multiple processing, cell culture, and separation techniques.
Complete qualitative and quantitative assays on cell therapy products including flow cytometry, qPCR and ELISA.
Comply with the facility's standard operating procedures and policies which incorporate FDA, FACT and CAP regulatory standards applicable to cellular therapy product production and analysis
Identify problems that may adversely affect product or testing performance and follow the Cell Therapy Facility standard operating procedures and policies whenever product processing or analytic testing are not within the defined acceptable criteria and/or levels of performance.
Handle fresh and frozen cellular products for shipment and infusion.
Maintain aseptic technique and work within a clean room environment.
Other duties as assigned.
Work schedule and/or shift adaptability is required. Periodic weekend work is also required based on production demands.Credentials and Qualifications
Bachelor's Degree in Medical Technology or other Biological Science.
Demonstrated competency in diverse biological processes following good documentation practices.
Demonstrated ability to work independently to achieve expected outcomesInterested candidates please click here or contact Andrea Cabellero directly at email@example.com
Posted 4/10/2019Applications are invited for a Postdoctoral Researcher with a joint appointment at the Morgridge Institute for Research and the University of Wisconsin Carbone Cancer Center. This multidisciplinary project is at the interface of cancer immunology (Dr. Paul Sondel’s lab, https://www.pediatrics.wisc.edu/research/research-groups/sondel) and cancer imaging (Dr. Melissa Skala’s lab, https://morgridge.org/skala). The objective of this research project is to develop novel cancer immunotherapies, and monitor immune-tumor cell interactions using optical microscopy. Measurements of tumor response to immunocytokines and radiation will be made in mouse models of cancer using in vivo microscopy, flow cytometry, and immunohistochemistry. Translational studies in human samples will provide preliminary data to motivate clinical trials of new immunotherapies. The Postdoctoral Researcher will work in collaboration with engineers, clinicians, and biologists/immunologists. The applicant will have access to state-of-the-art resources in cancer immunology, biomedical microscopy, and opportunities to develop skills in single cell analysis, cancer metabolism, and translational cancer research. This position will also provide a unique opportunity to gain experience in a multidisciplinary research environment.Qualifications of Applicant
Candidates should hold a doctoral degree in an appropriate field of engineering, the physical sciences, or biology. The applicant must be a capable experimentalist and have a desire to learn single cell analysis and new microscopy techniques. Previous experience in immunology and/or cancer research is particularly helpful. Excellent organizational and communication skills are a must.Application Process: Interested candidates should submit a curriculum vita, a list of three references and a one-page statement of research interests via: https://morgridge.org/job-posting/postdoctoral-research-associate-cancer-immunology-imaging/
Potential Start Date: May 1, 2019
Close Date: Until filled
Posted 4/1/2019The Clinical Research Coordinator is responsible for following University, Federal and sponsor guidelines, coordinate, perform and oversee clinical trials data management, scheduled trial treatments and follow-up care of clinical trials patients. Act as a liaison between the patient, caregivers, and healthcare team regarding current protocols as well as ensuring continuity of care while the patient is enrolled in the clinical trial.Salary Range: $25.03 to $40.24 Hourly
Final Filing Date: 04/20/2019
To view full job description and submit an on-line application visit: UC Davis Career Opportunities at: http://126.96.36.199/counter.php?id=157356
Requisition number #054905
The University of California, Davis is an Affirmative Action/Equal Opportunity Employer
Posted 3/15/2019The Department of Melanoma Medical Oncology as part of the Division of Cancer Medicine seeks a research faculty member at the Assistant/Associate Professor, Term Tenure Track level to join its full-time faculty. This opportunity provides an unmatched setting for the applicant with strong research interests in the areas of Melanoma Research and Immunology. The selected applicant should have expertise in applied basic and translational research, which may include T cell metabolism, immune evasion, antigen processing and presentation, cancer vaccines, cell therapy, and immune cell engineering. The candidate will be responsible for participating in innovative research programs providing balance and integrated educational programs for fellows, residents and students, serving on institutional committees, providing peer review, and serving as a role model to the laboratory technical staff. This position collaborates and should integrate with colleagues in Surgical Oncology, Pathology, Dermatology and other disease departments throughout the institution.MD Anderson, ranked #1 cancer center by U.S. News & World Report, is the world’s largest treatment facility for oncologic diseases. Located within the Texas Medical Center campus in Houston, our location provides access to a world-renowned medical community and the splendid cultural and recreational diversity of a sophisticated, metropolitan area that is the country’s fourth largest city.We are committed to the development of innovative therapies through the translation of basic science principles to the clinic. Areas of study include adoptive immunotherapy (using T-cells specific for tumors), vaccines (dendritic cells, peptides, recombinant virus), checkpoint inhibitors, novel cytokines and molecular targeting. Interested applicants should send a copy of their CV and letter describing their research interests and academic interests to:
Patrick Hwu, M.D., Chair and ProfessorMelanoma Medical OncologyDivision of Cancer MedicineUT MD Anderson Cancer Center1515 Holcombe Blvd., Box 430, Houston, TX 77030Email: firstname.lastname@example.orgMD Anderson Cancer Center is an equal opportunity employer and does not discriminate on the basis of race, color, religion, age, national origin, sex, sexual orientation, gender identity/expression, disability, veteran status, genetic information, or any other basis protected by federal, state, or local laws, unless such distinction is required by law. All positions at The University of Texas MD Anderson Cancer Center are security sensitive and subject to examination of criminal history record information. Smoke-free and drug-free environment.
Posted 3/15/2019The Department of Microbiology, Immunology and Cell Biology (http://medicine.hsc.wvu.edu/micro/) seeks a distinguished scientist as tenure-track faculty (rank open) to further its scientific exploration and discovery that targets cancer immunotherapy. The successful applicant will hold a primary faculty appointment in the Department of Microbiology, Immunology and Cell Biology as well as membership in the WVU Cancer Institute (http://www.wvucancer.org/home) in the WVU School of Medicine.This joint recruitment with the WVU Cancer Institute provides an exceptional opportunity to participate in robust, interdisciplinary basic and translational research and training programs in a highly collaborative atmosphere. The appointed faculty will be expected to conduct research on cancer immunotherapy and teach immunology to medical, graduate and undergraduate students. The successful candidate will be a recognized investigator with a PhD or MD/PhD degree and a track record of independent research, demonstrated by high quality publications in peer-reviewed journals and extramural funding commensurate with years of experience. Salary and academic rank will be commensurate with qualification and experience. Preferably, the selected candidate will hold active extramural funding in order to integrate rapidly with ongoing research at the intersection of immunology and oncology. Dedicated laboratory space and competitive operating funds will be made available.Founded in 1867, West Virginia University is 1 of only 11 research intensive land-grant institutions offering a single health sciences campus with accredited Schools of Medicine, Dentistry, Nursing, and Pharmacy and a formative School of Public Health. WVU is West Virginia’s major research and development center, and its only comprehensive doctoral-granting institution. Our faculty conduct research totaling over $138 million in sponsored contracts and grants per year. The Carnegie Foundation for the Advancement of Teaching classifies WVU as a comprehensive doctoral institution with medical programs – placing it among only 50 such public and 28 private institutions nationwide.Electronic submission of application with supporting credentials (including a cover letter, vitae, and list of three professional references) can be made at: https://wvu.taleo.net/careersection/faculty/jobdetail.ftl?job=10341. The position remains open until filled.General inquiries should be directed to:Rosana Schafer, Ph.D.Chair, Search Committeec/o Crystal May (email@example.com)Department of Microbiology, Immunology and Cell BiologyWest Virginia University School of MedicineMorgantown, WV 26506-9177West Virginia University is an Affirmative Action/Equal Opportunity Employer. The Health Sciences Center is a tobacco-free campus. West Virginia University is the recipient of an NSF ADVANCE award for gender equity. The University welcomes applications from all qualified individuals, including minorities, females, individuals with disabilities, and veterans.
Posted 3/7/2019Sutro Biopharma, located in South San Francisco, is developing a new generation of multi-functional antibody drug conjugate combination therapeutics and bifunctional antibody-based therapeutics for targeted cancer therapies. These therapeutics will significantly extend the clinical impact of current oncology therapeutic approaches and are beyond what can be envisioned with traditional cell-based expression technologies. Sutro’s biochemical synthesis technology, which underpins these therapeutics, allows the rapid and systematic exploration of many protein drug variants to research, discover and amino acids, takes approximately two weeks. Once identified, production of these protein drug candidates can be rapidly and predictably manufactured at commercial scales. In addition to developing its own drug pipeline, Sutro Biopharma is collaboration with select pharmaceutical and biotech companies in the research, discover, development, and manufacture of novel protein therapeutics.Sutro Biopharma is looking for a talented and energetic team player to help drive preclinical/clinical advancement of our drug portfolios within the Translational Pharmacology and Preclinical Development (TP/PD) group.Responsibilities
This pharmacology position requires a SRA/Scientist with at least 3 years industry experience in the preclinical development of cancer immunotherapies. The scientist will be responsible for validating therapeutics that have been engineered to engage a variety of immune effector pathways. Specifically, to develop novel animal models and conduct complex in vivo and ex vivo murine tumor studies with the goal of advancing leads to the clinic. The individual will be expected to:
Independently design, analyze, and report non-clinical animal pharmacology, pharmacokinetic (PK) and pharmacodynamic (PD) studies
Design flow cytometry (FACS) panels and perform FACS analysis on human and murine cells, tumors, and tissues
Develop novel murine models to investigate combinatorial immuno-therapeutic strategies
Assist in the training and supervision of other RA and SRA scientists
Communicate key scientific data to project teams with clear interpretation of data and proposal of next steps to all levels of the organization
Maintain expertise through current review of relevant literature
Nominate and evaluate novel targets to add to the Sutro portfolio
M.S. degree or higher (Ph.D. preferred) with a minimum of 3 years industry experience evaluating oncology or immuno-oncology drug products in preclinical efficacy models
Strong background in one or more areas of tumor biology, immunology, oncology, including immuno-oncology
Experience in the independent planning and execution of complex anti-tumor efficacy, PK, and PD studies in mice including: cell culture, dosing (IV, SC, IP), tumor measurement, as well as the dissection of organs for subsequent ex vivo analysis
Must be highly motivated and work successfully in cross-functional teams by contributing data and ideas
Demonstrated ability to multi-task, troubleshoot, think critically and interpret data
Clear and professional verbal and written communication skills, including maintaining detailed and accurate protocols and lab notebooksSutro provides a competitive benefits package that includes a choice of health, dental, and vision insurance, life insurance, flexible spending accounts, 401K plan, PTO, and stock participation.Please submit resume for Req. #1907 to firstname.lastname@example.org. Local candidates, SF Bay Area, no relocation. Please visit our website at www.sutrobio.com for more information.
Posted 3/7/2019Faculty Member: Nicola J. Mason
School: University of Pennsylvania’s School of Veterinary Medicine
Department: Clinical Sciences and Advanced MedicineDescription Post-doctoral position available immediately at the University of Pennsylvania’s School of Veterinary Medicine. The project is focused on the development and evaluation of next generation CAR T cells for the treatment of hematopoeitic and solid tumors and Chimeric Auto-Antigen Receptor T cells (CAART) for the treatment of autoimmunity in pet dogs with spontaneous disease. We have developed methodologies to generate canine CAR and CAAR T cells and have an active clinical trials program to evaluate the safety and efficacy of these approaches in client-owned, pet dogs with spontaneous cancers including B-NHL, glioblastoma and osteosarcoma and the spontaneous autoimmune diseases, pemphigus foliaceous and vulgaris. We are now developing next generation cellular immunotherapies to overcome the myriad of barriers to effector function in the tumor microenvironment. We seek a highly motivated and talented immunologist with an interest in translational research to work with both constitutive and inducible CAR related systems to manipulate the tumor microenvironment and enable safe and effective elimination of target cells. We work in close collaboration with colleagues at the University of Pennsylvania’s School of Medicine and are funded through both federal and private foundation mechanisms.QualificationsCandidates holding a doctoral degree (Ph.D. or MD/Ph.D or DVM/Ph.D.) in immunology, or cellular or molecular biology with a minimum of 2 years post-doctoral experience are eligible. Relevant cellular and molecular biology skills including primary cell culture, cloning and plasmid production, lenti and retrovirus production and cellular transduction, qPCR, flow cytometry (performance and data analysis/interpretation), and immune function analysis including cellular proliferation, cytokine production, cytotoxicity assays and ELISpot assays are required. Applicants must have excellent written and verbal communication skills.Please send your application including a cover letter describing your qualifications and research interests, an updated C.V. with a list of publications, and the names/addresses of three (3) references to: Dr. Nicola Mason at email@example.com
Posted 2/27/2019The Department of Microbiology and Immunology at the Penn State College of Medicine and the Penn State Cancer Institute invite applications from established mid-career or senior scientists engaged in basic and translational studies of cancer immunology and cancer immunotherapy research. The successful candidate will have an established, nationally/internationally recognized and extramurally funded research program focused on innate or adaptive cancer immunology with the potential to develop novel approaches for cancer immunotherapy. Successful candidates will have the opportunity to collaborate with an interactive group of basic science and clinical investigators with expertise in disciplines including immunology, virology, oncology, metabolomics, genomics, and drug discovery https://med.psu.edu/microbiology. State-of-the-art core facilities are available to support cutting edge research in live cell, single cell and genomic analysis and a high-performance computing facility is on site to support big data analytics. Faculty will be expected to participate in the teaching and training of graduate and medical students and contribute to the scientific and educational programs within the Cancer Institute. We offer a collegial research environment, competitive start-up packages and access to excellent trainees through our graduate programs. The Penn State College of Medicine is located in Hershey, Pennsylvania, a family-oriented community with top-ranked schools and convenient access to New York City, Philadelphia, Baltimore, and Washington D.C. Candidates should submit a curriculum vitae, a description of research interests (about two pages), and contact information for three references. Apply online at: https://psu.jobs/job/85240.To review the Annual Security Report which contains information about crime statistics and other safety and security matters and policies, please go to https://police.psu.edu/annual-security-reports, which will also explain how to request a paper copy of the Annual Security Report.Penn State is an equal opportunity, affirmative action employer, and is committed to providing employment opportunities to all qualified applicants without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.
Posted 2/21/2019Lab Manager/Lead Scientist position available in the Division of Hematology/Oncology at the University of California San Francisco. Our laboratory is pursuing novel immunotherapeutic approaches for the treatment of hematologic malignancies.UCSF is a highly collaborative environment and our laboratory is linked with multiple basic and clinical programs within the UCSF as well as with research at King's College, London.Applicant should have background in immunology and experience with: 1) Culture and manipulation of murine or human primary cells (PBMC, splenocytes, mobilized or bone marrow HSCs) and transformed cell lines. 2) Murine or human immune cell purification and functional analysis (proliferation, differentiation, cytokine production, signal transduction, and cell marker evaluation)3) Design, execution, interpretation of multi-parameter flow cytometric analyses4) Murine inbred and NSG models: maintenance and manipulation (IV and IP and SC injections, imaging, transplantation). 5) Plasmid and genomic DNA or RNA purification, cloning, transfection. 6) Preparation of, and transduction with viral vectors.7) Ph.D. or M.D. is preferred but not required.
Highly motivated candidates please send an application by email including a cover letter (describing your relevant qualifications, future interests, and expected start date), CV, names and contact information of three references to: Dr. Karin GaenslerDivision of Hematology/OncologyDepartment of MedicineUCSF School of MedicineEmail: firstname.lastname@example.org
Posted 2/13/2019Post-doctoral position immediately available in the Division of Hematology/Oncology at the University of California San Francisco. Our laboratory is pursuing novel immunotherapeutic approaches for the treatment of hematologic malignancies. Leukemia Lymphoma Society and CIRM funded studies are currently underway.L-15/IL-15Rα/CD80-expressing AML cell vaccines eradicate minimal residual disease in leukemic mice. Shi Y, Dincheva-Vogel L, Ayemoba CE, Fung JP, Bergamaschi C, Pavlakis GN, Farzaneh F, Gaensler KML. Blood Adv. 2018 Nov 27;2(22):3177-3192.UCSF is a highly collaborative environment and our laboratory is linked with multiple basic and clinical programs within the UCSF as well as with research at King's College, London.Applicant should have experience with: 1) Culture and manipulation of murine or human primary cells (PBMC, splenocytes, mobilized or bone marrow HSCs) and transformed cell lines. 2) Murine or human immune cell purification and functional analysis (proliferation, differentiation, cytokine production, signal transduction, and cell marker evaluation)3) Design, execution, interpretation of multi-parameter flow cytometric analyses4) Murine inbred and NSG models: maintenance and manipulation (IV and IP and SC injections, imaging, transplantation). 5) Plasmid and genomic DNA or RNA purification, cloning, transfection. 6) Preparation of, and transduction with viral vectors. Applicants must have a PhD or MD, and have excellent written and verbal communication skills. Highly motivated candidates please send an application by email including a cover letter (describing your relevant qualifications, future interests, and expected start date), CV, names and contact information of three references to: Dr. Karin GaenslerDivision of Hematology/OncologyDepartment of MedicineUCSF School of MedicineEmail: email@example.com
Posted 1/25/2019The T cell Immuno-Oncology (I-O) group in Pfizer is building a world-class immunology team and is seeking a highly motivated and creative Senior Principal Scientist to join a group of researchers evaluating novel therapies in the fields of Cancer Immunotherapy, Immune Checkpoint Biology, and Innate Immunity. The candidate will report to the Senior Director, Cancer Immunology and work closely with other disciplines across Pfizer to drive early discovery research programs into early clinical development, providing scientific and technical expertise. Specifically, the candidate will identify unique tumor-specific micro-environmental cues that impact T cell and dendritic cell function, differentiation and trafficking using a variety of tools including, classic molecular, cellular, and biochemical techniques, as well as modern imaging techniques, systems immunology, bioinformatics, and preclinical in vitro and in vivo models.Role Responsibilities
Supervise research associates and/or scientists.
Discover and develop new therapeutic modalities for cancer immunotherapy.
Design and perform studies to evaluate the anatomical distribution, persistence and function of antigen-specific T cells and dendritic cells in preclinical models of cancer.
Design and execute mechanism of action, PD and other biomarker studies, as well as combination studies for Pfizer’s preclinical-stage small molecule/IO drugs using in vivo murine models and ex vivo methods, such as cell sorting, multi-color flow cytometry, CyTOF, gene expression analysis techniques, and human and murine primary cell culture.
Collaborate with protein engineering, computational biology, T cell redirecting therapy group and clinical development group to pursue the most promising drug candidates through clinical trials.
Lead collaborations with internal and external collaborators.
Present at group meetings, global project team meetings, and site meetings.
Contribute to a dynamic, exciting culture that embraces teamwork and innovation.Basic Qualifications
Ph.D. with 8+ years experience.
Demonstrated expertise in the field of immunology, cell biology and/or genetics.
Solid technical knowledge and hands-on experience with conventional immunological techniques.
Broad experience in assessing T cell and/or DC function, differentiation, and memory development.
Expertise in flow cytometry, qRT-PCR, MSD, Nano string and cytotoxic assays.
Working knowledge of various murine tumor and/or infectious disease models.
Ability to independently design, plan and execute and interpret experiments
Prior experience working with or leading collaborations with external academic, biotechnology, and contract research organizations.
Experience in mentoring and/or leading Ph.D. level and non-Ph.D. level scientists.
Ability to organize and communicate complex data sets in a clear and concise manner to key stakeholders from diverse backgrounds.
Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic.Preferred Qualifications
Ph.D. with 8+ years of post-Ph.D. experience.
Ability to actively contribute scientifically to immunological drug discovery research programs, including identification and validation of novel targets.
In-depth understanding of T cell subsets and surface markers - Teff, Tem, Tcm,Trm, Treg Th1, Th2 etc.
In-depth understanding of dendritic cell biology.
In-depth understanding of inhibitory and co-stimulatory molecules and their associated signal transduction pathways.
Experience in CRISPR technology and lentiviral transduction.
Experience with human PBMC and mammalian cell culture.Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.Other Job Details:
Last Date to Apply for Job: March 1, 2019
Eligible for Relocation Package
Eligible for Employee Referral BonusInterested Candidates please apply at:
Posted 1/25/2019The T cell Immuno-Oncology (I-O) group in Pfizer is building a world-class immunology team and is seeking a highly motivated and creative Principal Scientist to join a group of researchers evaluating novel therapies in the fields of Cancer Immunotherapy, Immune Checkpoint Biology, and Innate Immunity. The candidate will report to the Senior Director, Cancer Immunology and work closely with other disciplines across Pfizer to drive early discovery research programs into early clinical development, providing scientific and technical expertise. Specifically, the candidate will identify unique tumor-specific micro-environmental cues that impact T cell and dendritic cell function, differentiation and trafficking using a variety of tools including, classic molecular, cellular, and biochemical techniques, as well as modern imaging techniques, systems immunology, bioinformatics, and preclinical in vitro and in vivo models.Role Responsibilites
Participate and/or lead collaborations with internal and external collaborators.
MS with 9+ years experience or Ph.D. with 4+ years of post-Ph.D. experience.
Demonstrated expertise in the field of immunology, cell biology and/or genetics.
Tel: +1 414 271 2456 | Fax: +1 414 276 3349 | Email: firstname.lastname@example.org