If you would like to place an ad on this page for a job opening you have at your organization, please download the agreement form (.DOC – .PDF) for the posting criteria and submit it, along with the job description, to firstname.lastname@example.org.
If you have any questions, please contact SITC at email@example.com or call 414-271-2456.
The Department of Immunology at The University of Texas MD Anderson Cancer Center is seeking applications for a term tenure-track faculty position at any level. We are seeking highly motivated individuals with a strong interest in fundamental immunology research as it relates to cancer. Candidates should demonstrate a record of high-level publications and a history of or strong potential for peer-reviewed research funding. Innovative investigators with immunology experience are welcome to apply.
The position offers the opportunity for scientific and professional growth and development with an exciting and active group of scientists whose diverse research interests comprehensively span the field of immunology. Located in a 132,000 sq.ft. research building, the department hosts state-of-the-art flow cytometry, CyTOF, single-cell sequencing, two-photon imaging, transgenic and gene-targeting, protein expression, hybridoma, and histology facilities. Our faculty study cellular and molecular mechanisms of innate and adaptive immunity. MD Anderson offers excellent opportunities for collaboration with clinicians, allowing investigators to translate their fundamental research to the cancer problem.
Competitive start-up packages will be provided to successful candidates. Houston, home of the Texas Medical Center with a wealth of exciting basic and clinical research across 54 institutions, offers an affordable cosmopolitan living environment and is ranked as the most diverse major city in the United States.
Interested applicants should submit their cover letter, current curriculum vitae, research plan, and contact information for three references to:
The University of Texas MD Anderson Cancer Center
Attn: Misty Hajek
Research Department Administrator
7455 Fannin Street, Suite 3.2013
Houston, TX 77054
MD Anderson Cancer Center is an equal opportunity employer and does not discriminate on the basis of race, color, religion, age, national origin, sex, sexual orientation, gender identity/expression, disability, veteran status, genetic information, or any other basis protected by federal, state, or local laws, unless such distinction is required by law. All positions at The University of Texas MD Anderson Cancer Center are security sensitive and subject to examination of criminal history record information. Smoke-free and drug-free environment.
The National Cancer Institute (NCI) is seeking candidates with a medical degree and experience in cancer immunotherapy for the position of Supervisory Physician (GP-602-15), Branch Chief of the Immuno-Oncology Branch (IOB), Developmental Therapeutics Program (DTP), Division of Cancer Treatment and Diagnosis (DCTD).
The candidate will serve as a Supervisory Physician/Branch Chief directing the activities of the IOB (https://dtp.cancer.gov/organization/iob/default.htm) and will collaborate with investigators of the DTP (https://dtp.cancer.gov/). The candidate will manage and coordinate all functions of the branch including planning, designing and executing preclinical research and clinical development of immunotherapy agents through a cross-functional collaboration within DTP and DCTD. As a senior advisor to the Division Director and Institute Director, the candidate will set priorities for federal investment in the development of new methods, technologies, and treatment paradigms that integrate immunomodulation strategies into clinical studies. The candidate is expected to manage and coordinate a system of grants and contracts to discover, investigate, develop and bring to initial clinical trials novel immuno-oncology products.
This is an exploratory ad to gauge interest and develop a possible candidate pool.
A vacancy announcement to fill the position will be posted on www.usajobs.gov at a later date.
This is a full-time government position. Compensation for this position will commensurate with the individual’s qualifications and experience as permitted within Federal government appointments. Individuals who apply must be U.S. citizens.
Please submit your resume, a statement of interest, and contact information for three references to Dr. Rosemarie Aurigemma, Developmental Therapeutics Program, National Cancer Institute at firstname.lastname@example.org or at (240) 276-5465 to address questions regarding this position.
DHHS, NIH, and NCI are Equal Opportunity Employers
The Research Scientist is a non-tenure track researcher who assumes the direct responsibility of conducting and performing experiments or directly overseeing experimentation as part of a research team under the general guidance of Dr. Shari Pilon-Thomas.
Research is focused on strategies to enhance Tumor Infiltrating Lymphocyte (TIL) therapy in patients
Opportunities for career advancement through attendance and presentations at nationals and international meetings
The Ideal Candidate:
Experienced scientist with knowledge in techniques and methodologies of Immunology
Familiarity and extensive experience with multi-color Flow cytometry
Experience with T cell culture, immunological assays, and processing human blood cells
Design, plan, and perform experiments with limited supervision
Attend and present work at scientific meetings and seminars
Report and disseminate knowledge gained in the laboratory through public presentation and manuscripts
Promote a collaborative environment within the laboratory and with outside collaborators
Provide supervision and guidance to other lab members with their ongoing projects
Credentials and Qualifications:
Minimum of a M.D. or Ph.D. in Biological Science or related field with three to five years of postdoctoral experience.
The person for the job should have the knowledge as specified by the Investigator.
Interested parties should submit their cover letter and CV to Dr. Pilon-Thomas using the following contact information:
Moffitt Cancer Center
Attn: Shari Pilon-Thomas, PhD
12902 Magnolia Drive
SRB-3, Immunology Department
Tampa, FL 33612
Apply directly at the following link: https://bit.ly/2QSOa9P
AbbVie is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company's mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world's most complex and serious diseases. Together with its wholly-owned subsidiary, Pharmacyclics, AbbVie employs more than 29,000 people worldwide and markets medicines in more than 170 countries. At AbbVie, our vision is to be recognized as a biopharmaceutical company delivering a consistent stream of innovative medicines that solve serious health issues and have a remarkable impact on people’s lives.
To be successful, we need outstanding individuals willing to challenge themselves to find the best solutions for our patients. The AbbVie Postdoc program is one way we are doing just that.
Through our Postdoc program, we are hiring postdocs from key academic institutions for preferred areas of science in the U.S., while providing a unique opportunity for participants to build a solid career foundation in the pharmaceutical industry while building the AbbVie brand as an employer of choice for scientific talent. The program offers a balance of structured learning and work experience, with accessibility to high-level knowledge building across the drug development continuum to help participants understand how everything fits together and is put into practice. It also provides them with a chance to establish working relationships with some of the world’s most respected scientists and leaders in the industry. Participants in the Postdoc program play an integral part in our continued success and will help us to further grow as a leader in our industry. This assignment is expected to be two years, minimally, and no more than three years.
AbbVie is at the forefront of cancer research, discovering and developing the next generation of treatments to address unmet medical need for cancer patients. Our strong pipeline includes both small molecule and biologic therapeutic approaches with first in class agents that target multiple pathways central to the growth and survival of both solid and hematological malignancies.
We are seeking a highly motivated postdoctoral scientist with a proven track record of research accomplishments to join our growing cancer research organization. The scientist will join a team dedicated to identify and validate targets associated with immunogenic cell death pathways.
Champion efforts to apply functional genomic screening technologies and chemical probes to identify and validate targets associated with immunogenic cell death pathways
Develop and maintain appropriate in vitro assays to measure immunogenic cell death phenotypes
Investigate the biological pathways and cross talk between tolerogenic and immunogenic cell death while developing a publication-driven research program.
Communicate results to multi-disciplinary teams
Successful completion and defense of a PhD in Cancer Research, Immunology, or related field
Demonstrated record of scientific achievement (i.e. strong publication in a top tier peer review journal(s)
Extensive laboratory research experience and desire to continue in a laboratory focused role.
Demonstrated experience in immunology/oncology with a strong working knowledge of innate and adaptive immune cell biology and tumor/immune cell interactions
Ability to independently develop novel assays and cellular models for interrogation of immunogenic cell death
Proficiency in standard biochemical, cellular and molecular techniques
Ability to multitask and work with timelines
Ability to thrive in a fast paced, multi-disciplinary environment interacting with a diverse group of experts within or outside of scientific discipline.
Enthusiasm and passion for conducting creative scientific research
Work authorization in the United States
Effective communication and teamwork skills
Excellent problem-solving skills including critical and analytical thinking.
Demonstrated scientific writing skills and strong verbal communication skills.
Proven track record of teamwork, adaptability, innovation, initiative, and integrity.
Global mindset to thrive in a diverse culture and environment. Demonstrated scientific writing skills and strong verbal communication skills.
Global mindset to thrive in a diverse culture and environment.
Key Leadership Competencies:
Builds strong relationships with peers and cross functionally with partners outside of the immediate team to enable higher performance
Learns fast, grasps the "essence" and can change course quickly where indicated
Raises the bar and is never satisfied with the status quo
Creates a learning environment, open to suggestions and experimentation to drive the science in the field of interest
Embraces the ideas of others, nurtures innovation and manages innovation to reality
For further information on the company and its people, portfolio and commitments, please visit www.abbvie.com. Follow @abbvie on Twitter or view careers on our Facebook or LinkedIn page. Equal Opportunity Employer Minorities/Women/Veterans/Disabled
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
The Center for Immuno-Oncology (CIO) is accepting applications for a scientist to coordinate and direct basic and translational biomarker research in immune oncology.
Qualified individuals will have a MS or PhD with experience in a basic science or translational clinical research laboratory and evidence of academic productivity. Such an individual will work closely with the medical directors of the CIO to develop tissue-based biomarkers to guide patient selection and therapies in the field of cancer immunology. Responsibilities will include overseeing 3 laboratory technicians, reviewing and preparing data, presenting at the weekly group meetings of the CIO and at national meetings, and contributing to high-impact publications. Such an individual oversee the transition of diagnostic tests developed by the CIO into clinical practice at the Center for Advanced Molecular Diagnostics (CAMD) at the Dana-Farber/ Brigham & Women's Cancer Center.
The CIO is multi-disciplinary group that includes investigators in basic and clinical research and dedicated to the discovery, development, and application of novel diagnostics and therapies in cancer immunology. A preferred candidate will be comfortable working independently and collaboratively and have strong management skills. Experience with the laboratory techniques used to study primary tissue samples, flow cytometry, gene expression profiling, and next-gen sequencing, is desired.
Advanced degree in Immunology, Molecular Biology, or related required.
3-5 years experience post education; one year management responsibility required. Level of Skill and Knowledge:
Basic tissue culture and molecular biology skills (e.g. qPCR, PCR) required
Flow Cytometry and ELISA/Luminex assays knowledge required
Mass Cytometry (CyTOF) preferred
Advanced knowledge of Flow Cytometry data analysis (e.g. FlowJo, Cytobank) required
Theoretical and practical knowledge of Next Generation Sequencing sample preparation workflows and applications and experience Ion Torrent sequencing platform is preferred.
Immunology and/or Oncology research experience preferred.
Must have excellent personal task management skills and high level of self-motivation
Excellent verbal and written communication skills and willingness to collaborate cross-departmentally required.
Demonstrated success in technical proficiency, scientific creativity, collaboration with others and independent thought. Works on problems of diverse scope in which analysis of data requires evaluation of identifiable factors. Exercises judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions.
Scope of Leadership and Level of Supervision
Manages the work efforts of one or more technicians. Is responsible for mentoring. Completes performance appraisals. Works closely with senior managers and directors on unit/lab issues. Wide latitude for decision-making working in conjunction with PIs.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.
Apply Here: http://www.Click2apply.net/cv8y5qsxmv5w5nm2
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.
AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at AbbVie Biotherapeutics, AbbVie's immuno-oncology center in Redwood City, CA.
With appropriate supervision, manages the design and implementation of study protocols for a clinical development program in support of the overall Product Development Plan, based on strong medical and scientific principles, knowledge of compliance and regulatory requirements, AbbVie’s customers, markets, business operations and emerging issues. Oversees project-related education of investigators, study site personnel and Abbvie study staff. Responsibility will focus on early clinical development program activities but may extend to later stage development activities and product lifecycle management strategies for internal programs
Key Responsibilities Include:.
* Responsibility for review, interpretation, and communication of accumulating data pertaining to safety and efficacy of the molecule. Along with Clinical Operations, may be responsible for oversight of study enrollment and overall timelines for key deliverables.
* Contributes to design, analysis, interpretation and reporting of scientific content of protocols, investigator Brochures, Clinical Study Reports, regulatory submissions and responses and other program documents.
* May be asked to contribute to the development of a rigorous, cross-functionally-aligned, vetted Clinical Development plan in collaboration with matrix team members.
* Participates in opinion leader interactions related to the disease area(s); partners with Research, Medical Affairs, Commercial and other functions in these activities as required, consistent with corporate policies.
* Stays abreast of professional information and technology through conferences, medical literature and other available training, to augment expertise in the therapeutic area.
* Responsible for understanding the regulatory requirements related to the clinical studies and global drug development and accountable for complying with those requirements. May be asked to contribute to regulatory responses and discussions.
* Ensures adherence to Good Clinical Practices, pharmacovigilance standards, standard operating procedures and to all other quality standards in conducting research.
* PharmD/PhD with 4+ years pharmaceutical industry experience.
* Oncology development experience, specifically early development, is highly preferred.
* Ability to provide input and direction to clinical research with appropriate supervision.
* Strong desire to collaborate in a cross-functional setting.
* Clinical of early phase clinical trial experience in the pharmaceutical industry, academia, or equivalent is preferred.
* Knowledge of clinical trial methodology, regulatory and compliance requirements governing clinical trials and experience in the design of study protocols is desirable.
* Ability to interact externally and internally to support global scientific and business strategy.
* Must possess excellent oral and written English communication skills.
Equal Opportunity Employer Minorities/Women/Veterans/Disabled
URL for your website or original job posting:
Job Contact Information: email@example.com, Tim Silcott, 650-296-4528
Dr. Yagi’s digital pathology laboratory at the Josie Robertson Surgical Center serves as an incubator to explore and evaluate new technology to advance digital pathology in a clinical setting and actively engage vendors to help improve the technology and develop clinical applicability. The practical use of digital pathology for primary diagnosis requires the development of useful analytic algorithms to compensate for the reduced efficiency of slide review inherent in current digital slide interface applications, and at MSK, we are uniquely positioned to develop these algorithms while addressing the user experience. Collaborations with clinical departments (e.g., Surgery), Radiology, Medical Physics, and Informatics groups will enhance the assessment and create opportunities for multidisciplinary applications. Your role as Research Fellow in Dr. Yagi’s laboratory is critical to our research and development.
Unless agreed upon in advance to your appointment at MSK, the Research Fellow is expected to work Mondays – Fridays; 9am to 5pm. You will be assigned a workstation in Dr. Yagi’s laboratory located at:
Josie Robertson Surgical Center
Room – JRSC 1020
1133 York Avenue
New York, NY 10065
Research Fellows at MSK are allotted 20 personal days that can be used upon written request and approval from Dr. Yagi at minimum one week in advance of desired dates. Sick and emergency days needed require proper call out protocol as per the Pathology Department and MSK’s policies on attendance and time away.
Research Fellows are also allotted the National Holidays; which are separate from the 20 days above:
New Years Day – Jan 1
Memorial Day – last Monday in May (date varies yearly)
Independence Day – July 4th
Labor Day – first Monday in Sep (date varies yearly)
Thanksgiving Day – third Thursday in Nov (date varies yearly)
Christmas Day – Dec 25th
Time needed to attend conferences and work related events will be discussed and coordinated in advanced and also require prior approval from Dr. Yagi, department administration, and/or MSK administration; as applicable.
Meetings and Conferences:
Annual Symposium for the Warren Alpert Center for Digital and Computational Pathology at MSK. The Research Fellow will be expected to present at MSK twice during their academic appointment:
Fall – internal presentations to MSK pathology faculty and staff; MSK clinicians; and invited guests
Spring – year end presentations of final research projects to MSK faculty and staff and opened to registrants
Weekly 1:1 meetings with Dr. Yagi for 30 mins.
This is your time to check in with Dr. Yagi for feedback on your projects and/or to communicate updates, challenges, issues, and/or concerns.
Biweekly Team Meetings – Every other Friday (10:30am-12pm)
All members of Dr. Yagi’s team are expected to present updates on their research projects following the provided format and time allotted.
Monthly Journal Club Meetings – Third Wednesday (3pm – 4pm)
Journals and topics in the field of digital and computational pathology are presented and discussed. The Research Fellow is highly encouraged to give one presentation; discussed and approved with Dr. Yagi in advance.
The Research Fellow is required to attend these meetings; unless approved in advance by Dr. Yagi to not attend.
Working Group Meetings – Ad Hoc and as needed
The Research Fellow is expected to attend all working group meetings for the research projects he/she is leading and/or collaborating.
The Research Fellow is expected to coordinate working meetings with the MSK pathologists, MSK clinicians, etc as it pertains to his/her assigned projects. If assistance is needed; the Research Fellow can coordinate with Dr. Yagi’s research coordinator; Christina Virgo. The Research Fellow is responsible for the action items and follow up to ensure projects progress in a timely manner.
Deliverables at Completion of Research Fellowship:
The Research Fellow is expected to present an abstract by December for review; to be submitted to USCAP.
The Research Fellow is expected to publish shortly after USCAP; assuming the abstract was accepted. Drafts of publications are due to Dr. Yagi by end of March for review. The Research Fellow is to identify the journals for which he/she will submit; if not already discussed before hand with Dr. Yagi.
Develop a Manuscript and or Standard Operating Procedure Manual to go hand in hand with your research project; as applicable. Dr. Yagi expects detailed written documentation of all testing and validation results; which are to be saved and stored in a central location as identified by Dr. Yagi.
Team Work and Collaboration:
All Research Fellows are expected to work collaboratively with all members of Dr. Yagi’s team and collaborators both internally and externally. Professionalism is expected at all times as you are a representation of Dr. Yagi’s laboratory, the Warren Alpert Center for Digital and Computational Pathology, the Department of Pathology, and the MSK team!
Communication is key; as is accountability! As you’ll quickly learn working in Dr. Yagi’s laboratory; most projects will overlap and we rely on each other’s expertise to obtain optimal results. We also have biweekly team meetings where each member is expected to present an update on their current project. This is an opportunity for Dr. Yagi and your team members to learn more about your project and progress and provide feedback.
If there are ever any issues and/or concerns; please discuss them with Dr. Yagi immediately and/or reach out to your Human Resource partner at MSK.
Confidentiality and Proper Disclosure:
All Research Fellows are expected to abide by MSK’s policies and procedures as it pertains to confidentiality and proper disclosure for possible conflicts of interests. It is the Research Fellow’s responsibility to disclose any and all possible conflicts of interests as per MSK’s policies. All Research Fellows are expected to review the policies and procedures on this matter upon starting in Dr. Yagi’s laboratory. If you have any questions and/or concerns or aren’t sure if a policy pertains to you – please ask us!
Interested applicants can contact Jennifer Samboy, firstname.lastname@example.org.
We look forward to having you as part of our team this year!
The candidate will serve as a Supervisory Physician/Branch Chief directing the activities of the IOB (https://dtp.cancer.gov/organization/iob/default.htm) and will collaborate with investigators of the DTP (https://dtp.cancer.gov/). The candidate will manage and coordinate all functions of the branch including planning, designing and executing preclinical research and clinical development of immunotherapy agents through a cross-functional collaboration within DTP and DCTD. As a senior advisor to the Division Director and Institute Director, the candidate will set priorities for federal investment in the development of new methods, technologies, and treatment paradigms that integrate immunomodulation strategies into clinical studies. The candidate is expected to manage and coordinate a program that includes grants and contracts to discover, investigate, develop and bring to initial clinical trials novel immuno-oncology products.
A vacancy announcement to fill the position is posted on www.usajobs.gov. To apply, please visit: https://www.usajobs.gov and search NIH-SR-DH-18-10270590.
This is a full-time government position. Compensation for this position is commensurate with the individual’s qualifications and experience as permitted within Federal government appointments. Individuals who apply must be U.S. citizens.
DHHS, NIH and NCI are Equal Opportunity Employers.
The EACRI, a division of the Providence Cancer Institute, at the Robert W. Franz Cancer Center invites applicants for full-time faculty positions in Immuno-oncology. The rank is open and will depend on the candidate’s research accomplishments. We are seeking energetic, creative and innovative individuals to complement a strong team of cancer immunologists. Applicants must hold a PhD and/or MD degree in immunology or related discipline. Applicants can be an established investigator with a strong record of published research in immunology and demonstrated success in garnering external funding or a junior faculty candidate with a clear vision of how to establish a funded, productive research laboratory. Competitive start-up funding is available. Additional information on our Institute can be found at www.franzcancer.org.
Apply now by sending your curriculum vitae, a one page description of current and future research interests, and names and contact information of three references to email@example.com.
The Markowitz lab is seeking a Postdoc Fellow or Research Scientist whose skills and personal and professional experience have prepared them to contribute to our commitment to diversity and excellence.
The lab’s research interest is in studying immune suppressor cells, their role in the development of melanoma, and means of inhibiting their actions. We are also developing tools to predict which patients are likely to fail immune-based therapy via novel high dimensional flow cytometric, mass spectrometry and informatics techniques, allowing those patients to be treated with other potentially more effective therapies. We are a translational laboratory striving to translate the knowledge gained in the laboratory via immune-based and traditional biochemical approaches to the clinic. https://moffitt.org/providers/joseph-markowitz/
The postdoctoral fellow/research scientist is a non-tenure track researcher who assumes the direct responsibility of conducting and performing experiments or directly overseeing experimentation as part of a research team under the general guidance of Dr. Markowitz.
Develop biomarkers for immune-based therapy.
Study resistance mechanisms to immune checkpoint blockade.
proficiency in flow cytometry, IHC, immunoblot, cell culture techniques, general immunology
comfortable with murine experiments,
general proficiency in computers, general familiarity with bioinformatics and statistics preferred.
Manage projects under general supervision.
General laboratory techniques such as flow cytometry, murine experiments, informatics (assistance will be given with coding, but need to understand the basics to apply it and make small changes), immunohistochemistry, immunoblots, cell culture, ELISA, proliferation assays, immunoprecipiation
Technical writing of research papers and assistance with grants.
M.D. or Ph.D. in Immunology, Bioinformatics, Cancer Biology
Research Scientist required having a minimum of 3 years as a Postdoc Fellow.
A competitive salary and benefits package will be offered to the successful candidate.
Moffitt is located in Tampa, Florida, which is a thriving city with a low cost of living, excellent culture and outstanding restaurants, and a high quality of life. This position requires someone who can appreciate the sunshine, the nation’s top beaches, and year-round golf, biking, boating, fishing, tennis, swimming, snorkeling and other recreational activities that are associated with the Gulf Coast of Florida.
To formally apply: visit https://moffitt.org/careers-education/. Interested applicants should attach a single PDF file that includes a current CV and cover letter expressing interest with this position to either the Postdoc req 27406 or Research Scientist Req 27435.
AbbVie Stemcentrx is currently offering a unique opportunity for a highly motivated individual to join our team as a Director, Companion Diagnostics Pathology. The Companion Diagnostics Pathology Group resides within the Companion Diagnostics Center of Excellence (CDx COE), which supports CDx development across Abbvie. The successful candidate will provide leadership and expertise in human disease pathology and molecular pathology to support the clinical development of tissue-based companion diagnostics for oncology drug candidates. As a member of the development project teams he/she will have the opportunity to work in a highly collaborative environment and to support projects throughout clinical development.
Key Responsibilities Includes:
* Lead the identification and development of tissue-based biomarkers, including their characterization and validation (biomarker prevalence, clinical utility for patient selection/stratification, relevant cutoffs, etc.) and the proposed pathology assays (specificity and sensitivity, scoring system, etc.)
* Design, implement and oversee pathology based biomarker and diagnostic testing and data analysis for clinical development studies:
o Direct the development, outsourcing and validation of clinically applicable tissue based assays. Assists in the development of assay protocols as needed.
o Write the relevant pathology based biomarker and diagnostics testing sections in drug development and registration documents such as clinical study protocols, clinical study reports, investigator brochures, and regulatory submission packages (INDs, NDA’s,BLA's).
* Provide pathology input to development project teams and ensure access to state of the art tissue based techniques and samples for target pathway evaluation in human disease:
o Implement technologies and/or methodologies as needed, via a combination of in-house efforts and the use of CROs or other external expertise using techniques such as in situ hybridization, immunohistochemistry, IHC multiplexing, fluorescence applications, use of image analysis algorithms, laser capture microdissection, RNAseq, qPCR, etc.
o Evaluate the scientific basis and clinical applicability of the proposed assays, their validation status and any related technical issues.
o Assume responsibility for the assessment and scoring of specimens and the preparation of reports summarizing the data, analysis and interpretation of findings.
o Collaborate with project teams from concept to reagent generation to quantitation and approval plan for CDx as needed.
* Participate in the evaluation of external licensing or collaborative opportunities (including CDx collaborations), and oversee internal components of shared programs.
* Lead and participate in project development teams or sub-teams as needed. Coordinate with appropriate team members to advance projects efficiently.
* Highly experienced pathologist (MD, PhD, or DVM degree) with 8+ years of relevant post-doctoral academic, clinical and/or industry pathology experience. Board certification in the United States is desirable but not required.
* In depth experience with the discovery, characterization, clinical validation and utilization of tissue based biomarkers and potential diagnostics:
o Awareness of the challenges of implementing tissue based biomarker and diagnostic technologies in the clinical setting
o Direct experience in development, outsourcing and validation of clinically applicable tissue based biomarker assays
* A proven Molecular Pathology track record with credible publications and Pathology support for research and clinical science:
o Demonstrated expertise in tissue-based analysis such as in situ hybridization, immunohistochemistry, fluorescence applications, laser capture microdissection
o Expertise with human diseases and evaluation of disease pathogenesis with tools such as experimental mouse models
o Expertise with image analysis software and algorithm design
* Demonstrated excellence in independently leading and conducting research and ability to summarize information/data in a concise, easy to understand manner
* Excellent leadership skills including mentoring, motivation and delegation
* Excellent verbal and written communication and presentation skills in English
* High level of initiative and ability to work independently
* High level of business awareness
About USUHS: The mission of the USUHS is to educate, train, and comprehensively prepare uniformed services health professionals, scientists, and leaders to support the Military and Public Health Systems, the National Security and National Defense Strategies of the United States, and the readiness of our Uniformed Services. USUHS is integral part of F. Edward Hébert School of Medicine. Within campus, we collaborated with Armed Forces Radiobiology Research Institute and with Murtha Cancer Center, Walter Reed, capital Breast care project. USUHS is located in close proximity to National Institute of health, providing opportunities for cross campus collaboration. More info: https://www.usuhs.edu/
Core facilities at USUHS: https://www.usuhs.edu/research/core-facilities
About Geeta Upadhyay: Dr. Upadhyay recently joined USUHS faculty as tenure track faculty. Dr. Upadhyay received her training at Harvard, NCI, UTHSCSA, Georgetown University. Her research is focused on biomarker discover, drug development and drug resistance in breast cancer.
Click here for a complete list of publications.
PROJECT DESCRIPTION: The postdoctoral candidate will have the opportunity to conduct some of the research described in our newly funded R01 grant title “Role of Ly6K in TGF-beta and immune escape pathways of triple negative breast cancer”. Ly6K, a GPI anchored protein, is expressed in cancer tissue and is required for in vivo tumor progression. We have shown that Ly6K activates TGF-beta signaling, epithelial-to-mesenchymal transition and PD-L1 expression. We found that knockdown or pharmacological inhibition of Ly6K by small molecules binders, can significantly inhibit multiple distinct aspects of the biological activity of Ly6K. This proposal will be focused on determining the molecular basis of Ly6K action and Ly6K targeted therapeutics.
Flow cytometry: Sample prep, execution on the machine, data analysis, sorting and multicolor panel
Cell culture: Primary and cell lines, T cell expansion.
In vivo studies: Mouse handling, i.p. injections, tumor injections and
measurements, immunotherapy assays, tissue collection and processing, mouse genetics.
In vitro and ex vivo assays: cell signaling, live cell imaging, westerns, qRT-PCR, luminex.
Upadhyay G, Yin Y, Yuan H, Li X, Derynck R, Glazer RI. Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling. Proc. Natl. Acad. Sci. U.S.A., 108, 7820–7825 (2011). PMID: 21518866.
AlHossiny M, Luo L, Frazier WR, Steiner N, Gusev Y, Kallakury B, Glasgow E, Creswell K, Madhavan S, Kumar R, Upadhyay G. Lymphocyte antigens 6 complex K/E-transforming growth factor-beta axis promotes breast cancer tumorigenesis. Cancer Res., 76, 3376–3386 (2016). PMID: 27197181.
Luo L, McGarvey P, Madhavan S, Kumar R, Gusev Y, Upadhyay G. Lymphocyte antigens 6 complex gene family members drive tumorigenesis. Oncotarget, 7, 11165–11193 (2016). PMID: 26862846
Click here to apply for the postdoctoral position at USUHS website.
Heal the sick, Advance the science, Share the knowledge.
The successful candidate will be an immunologist with expertise in senescent remodeling of the immune system with aging and will lead an independent and nationally and internationally-recognized research program. This person will hold academic rank at Mayo Clinic commensurate with experience and qualifications. The ideal candidate will target the profound changes that occur in the immune system with age and how such changes can be linked with the progression of a variety of chronic illnesses and increased risk of acute infections, using cutting edge technologies. Specific areas of interest may include effects of age on micro- environmental niches supporting adaptive immune cell development, cell intrinsic physiologic changes in long-lived adaptive immune cells, age-related extrinsic stresses impacting immune cells and the aging of the innate immune system. Faculty will be expected to work collaboratively with colleagues and to be an active participant in the enterprise-wide Department of Immunology and the Robert and Arlene Kogod Center on Aging. The individual may also align with other Mayo Clinic centers such as cancer, transplant, cardiovascular diseases, biomedical discovery, individualized medicine and regenerative medicine.
QUALIFICATIONS: Credentials of a successful candidate will include a doctoral degree (PhD, MD/PhD, MD or equivalent) in a biomedical science field and rigorous postdoctoral training. Junior investigators should have a strong publication record; evidence of successful competition for external funding is preferred. Mid-career investigators must have a strong publication record and history of NIH- or equivalent extramural funding.
MAYO CLINIC is an integrated, multidisciplinary academic medical center with comprehensive programs in medical education and research that span across three group practice and research sites. We support a vibrant and diverse research enterprise, with programs in basic, translational, clinical, and population sciences. Mayo has world-class faculty, laboratories, and state-of-the-art core facilities and biorepositories. The Mayo Clinic Graduate School of Biomedical Sciences trains and supports PhD and MD/PhD students.
We offer a highly competitive compensation package with sustained salary support, capital equipment funding, technical and computational resources, and exceptional benefits. Mayo Foundation is an affirmative action and equal opportunity educator and employer that values and promotes diversity as a strategic advantage.
Mayo Clinic's campuses in Arizona are located in Phoenix and Scottsdale, in the beautiful Sonoran Desert. With Phoenix being the sixth largest city in the nation, this sunny "desert metropolis" offers the amenities of a big city in the midst of a strikingly beautiful, rugged, southwest landscape.
Scottsdale frequently earns praise as a highly desirable place to live. The city's more than 200,000 residents enjoy a vibrant mix of culinary hot spots, arts and entertainment, professional and collegiate sports teams, and community resources. The region's desert climate promotes an outdoor lifestyle with a full complement of sports and recreation.
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Applications should include a cover letter, CV and a statement of research interests. Specific questions should be directed to:
Dr. Sandra Gendler, Ph.D. Department of Immunology Chair, Search Committee C/O Adriana Semko firstname.lastname@example.org.
©2018 Mayo Foundation for Medical Education and Research. Post offer/pre-employment drug screening is required. Mayo Clinic is an equal opportunity educator and employer (including veterans and persons with disabilities). As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica®, Venclexta™, and Empliciti™ — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.
AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at Stemcentrx, AbbVie's South San Francisco, CA location.
As part of a talented and multi-disciplinary team advancing an exciting novel approach to drug development, the successful candidate will lead method validation and transfer activities associated with QC testing of the Company’s GMP products.
The successful candidate will be responsible for providing strategic leadership and technical expertise overseeing in-house validation and method transfer activities as the company progresses through clinical trials. This is a hands-on role that requires close collaboration with Quality Control, Analytical Development, Research, Manufacturing, Quality Assurance and Regulatory groups.
Primary Duties and Responsibilities:
* Coordinate/collaborate with the Analytical Development and Research Bioassay teams to define methods required for the control system for release and stability testing of monoclonal antibody intermediates, antibody-drug conjugate drug substances and drug products
* Coordinate/collaborate on method optimization and transfer from the Analytical Development and Research Bioassay Teams to Quality Control
* Oversee determination of appropriate system suitability criteria based on data trending
* Establish appropriate timelines for QC validation activities
* Establish validation strategies that are phase appropriate and drive validation strategy and execution to meet required timeline
* Prepare and provide technical review of relevant documentation including test methods, transfer documentation, validation protocols, reports and raw data
* Approve final test methods after validation in alignment with control strategy as well as after any revisions
* Serve as a technical advisor to the critical reagent control and monitoring program
* Collaborate on the development of specifications for intermediates, drug substances, drug products and reference standards
* Assist in the preparation of CMC regulatory submissions
* Implement new technology and instrumentation into QC lab to maintain state-of-the-art control systems
* Provide technical expertise necessary for troubleshooting instrumentation, investigating unexpected results/deviations, optimizing QC methods and developing appropriate CAPAs
Required Skills and Specifications:
* In-depth knowledge of analytical methods used for monoclonal antibodies and antibody-drug conjugates (Bioassay experience a plus)
* Experience with optimizing assays for a QC environment, including defining appropriate system suitability
* Demonstrated track record of leadership in method validation activities, including development of supporting documentation and managing timelines
* Experience managing method transfers
* Experience with LIMs systems and electronic document management and quality management systems a plus
* In-depth experience with regulatory/pharmacopeia requirements for biologic product testing and validation
* In-depth knowledge of FDA, EMA, GMP, WHO and ICH regulatory requirements
* Excellent interpersonal skills, organizational skills and communication skills including the proven ability to manage direct reports and influence collaborators in other departments
* Excellent verbal and written communication skills
* Ability to operate in a fast-paced, multi-disciplinary industrial environment
* A minimum BS, but preferably an MS or Ph.D in Biological Sciences, Biochemistry or Chemistry
* Minimum of 8+ years of experience in the biotechnology or pharma industry with experience in biologics
To apply for this position, click here: https://ars2.equest.com/?response_id=9e0e64055b0ca77acbb0cc287ba2d1a4
We are looking to hire post-doctoral scientists in the fields of tumor immunology and cancer immunotherapy. The positions are available in the laboratory of Dr. Samir N. Khleif at the Lombardi Comprehensive Cancer Center (LCCC), Georgetown University Medical Center in Washington DC. The major focus of the lab is the basic and translational research that is dedicated to understanding the cellular/molecular mechanisms underlying immune cell activation, localization and immunosuppression within the tumor microenvironment. Another major focus of the lab is to decipher the mechanisms leading to resistance to cancer immunotherapy.
The ideal candidates will hold a PhD/MD in Immunology, Cancer Biology, Cell Biology or Molecular Biology. A deep and thorough understanding of the T cell biology, various immune mechanisms is mandatory for this application. In addition, for one of the positions knowledge of mouse models of obesity is required. Experience in the area of in vivo cancer biology is a plus. The required skills include but are not limited to: mouse models, immunohistochemistry, flow cytometry, in vitro assays.
Candidates must be proficient in oral and written English, excellent communication, and multi-tasking skills, and be team-oriented, proactive and results driven. Candidates are invited to apply for competitive fellowships during their stay in the lab.
The positions can start between July-August, at the earliest. The starting date can be flexible. Interested candidates should send their resume, containing a list of publications, a summary of past research, contact information of 2 or 3 referees, and a motivation letter in a single.pdf file to email@example.com or firstname.lastname@example.org.
About the Lab
The Khleif Laboratory offers a highly competitive, stimulating and dynamic working environment within an exceptional scientific setting in an international, young, enthusiastic, motivated team. The laboratory is working on high-impact projects and conducts research that can be translated into the clinical practice. The laboratory is part of the LCCC, a multidisciplinary research center focusing on cancer, genetics, metabolism and immune-therapy. LCCC offers many core facilities including: Imaging, Molecular Biology, Metabolomics, Histology and animal facility, etc. Technical support is granted within the lab. Remuneration is competitive. Georgetown University is an equal opportunity employer and all eligible candidates irrespective of their social background are welcome to apply.
Job Type: Full-time
AbbVie is expanding its oncology efforts with a focus on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these multiple sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is located at the AbbVie site in Redwood City, CA.
Director, Immuno-Oncology Clinical Biomarkers
We are searching for a Director of Immuno-Oncology Clinical Biomarkers (I-O CB) to join Oncology Early Development (OED). This is a unique opportunity to lead a team of scientists that drive the strategy and implementation of the clinical biomarker plans across innovative first in-class, cutting edge programs, in the area of Immuno-Oncology.
In this role, you will report directly to the Group Project Leader in Oncology Early Development (OED) and will join an experienced team with a strong track record in developing biotech products. As the Director of I-O CB, you will lead a team of clinical biomarker scientists that participate in cross-functional OED teams. The scope of OED is clinical candidate nomination through the end of clinical proof of concept. As a Director of I-O CB, you will be responsible for the development and execution of comprehensive biomarker plans that will enable science based decision making on the clinical programs. You will liaise with Project Director, Medical Director, preclinical biomarker leads, discovery leads, and experts in pharmacokinetics/pharmacodynamics (PK/PD) to develop and implement the clinical biomarker strategies for OED stage I-O assets. You will also help guide IND enabling preclinical biomarker studies, help draft and review regulatory documents (such as INDs),
Investigator Brochures and clinical protocols, design clinical biomarker studies for OED stage compounds. To be successful in this role, you need a deep understanding of cancer immunotherapy and related development, and convincingly articulate the rationale for the biomarker plans to senior management and governance committees within AbbVie. You will be a clinical scientific leader of I-O CB within the organization.
Key goals include:
The Developmental Therapeutics Program (DTP), of the NCI, is seeking candidates with an advanced degree in Biology, Microbiology, or equivalent for the position of Branch Chief, Biological Resources Branch (BRB).
The candidate will be a Supervisory Biologist directing the activities of the BRB (https://ncifrederick.cancer.gov/research/brb/) and will collaborate with investigators of the NCI DTP (https://dtp.cancer.gov/). The candidate will manage and coordinate all functional requirements for the branch including preclinical development research, clinical manufacturing and testing of biopharmaceutical products, and related studies pertaining to the extramural work of the BRB. The agents to be developed and manufactured in this program are biopharmaceutical and immunotherapy agents including, but not limited to, recombinant proteins, peptides, vaccines, monoclonal antibodies, genetically modified viruses, bacteria or mammalian cells, immunomodulating agents, cytokines and growth factors, tumor antigens, and nanotechnology-based biopharmaceutical products. The Chief manages and coordinates a system of grants and contracts to discover, investigate, develop and bring to initial clinical trials selected biologics and biopharmaceuticals with the intent of producing a therapeutic affect that alters the biology of cell growth and metastasis.
This is an exploratory ad to gauge interest and a possible candidate pool. A vacancy announcement (VA) to fill the position will be posted on WWW.USAJOBS.GOV at a later date.
Candidates must be U.S. citizens. Compensation for this position is commensurate with the individual’s qualifications and experience as permitted within Federal Government appointments.
Please submit your C.V., a statement of interest, and contact information for three references to Dr. Rosemarie Aurigemma, Developmental Therapeutics Program, National Cancer Institute at email@example.com (phone 240-276-5465).
DHHS, NIH, and NCI are Equal Opportunity Employers.
The Developmental Therapeutics Program (DTP), of the NCI, is seeking candidates with an advanced degree in Toxicology, Pharmacology, or equivalent for the position of Branch Chief, Toxicology and Pharmacology Branch (TPB).
The candidate will be a Supervisory Toxicologist directing the activities of the TPB (https://dtp.cancer.gov/organization/tpb/) and will collaborate with investigators of the NCI DTP (https://dtp.cancer.gov/). The candidate will manage and coordinate all functional requirements for the branch including formulation of research and/or testing the biological, toxicological, carcinogenic potential of chemicals, and/or biopharmaceutical agents and make recommendations for the development of new or revised programs to meet existing needs in the areas of toxicology, pharmacology, and pharmacodynamics.
The candidate initiates and develops research projects investigating mechanisms underlying the toxicity of chemicals, classes of chemicals, or other agents or important topics related to cancer therapeutics research. Candidates with interest in developing model systems for predicting and measuring toxicological and pharmacological properties of anticancer agents are of particular interest.
Please submit your C.V., a statement of interest. and contact information for three references to Dr. Rosemarie Aurigemma, Developmental Therapeutics Program, National Cancer Institute at firstname.lastname@example.org (phone 240-276-5465).
The Department of Laboratory Medicine at Memorial Sloan Kettering Cancer Center, New York seeks a Clinical Laboratory Immunologist. The Memorial Hospital for Cancer and Allied Diseases is a worldwide leader in cancer treatment and diagnosis, consistently voted as one of the best specialty hospitals in the nation. The Department of Laboratory Medicine provides diagnostic testing for all patients seen at Memorial Sloan Kettering Cancer Center (MSKCC). The Department is comprised of the following services: Clinical Chemistry, including Point-of Care, Hematology, including Coagulation and Cellular Immunology, Microbiology, Cellular Therapy, Transfusion Medicine, including blood bank, donor room and apheresis, and jointly with the Pathology Department, Hematopathology. The main campus operation is comprised of seven laboratories and the highest-volume hospital-based blood donor room in the City of New York. In addition, there are six regional sites located in New Jersey, Westchester, Long Island and several outpatient sites in Manhattan that collect specimens and perform limited testing on site.
The Cellular Immunology Laboratory performs over 35 thousand tests annually and is a highly advanced laboratory with a staff of 15 technologists, a supervisor, manager, and one Medical Service Chief. The environment provides substantial opportunities for clinical/translational research, as well as collaboration with investigators throughout MSKCC. The successful candidate will have the opportunity to participate in an expanding program focused on service, research and teaching. Several programs at Memorial Hospital are currently expanding resulting in increased tests volumes. The Department of Laboratory Medicine is concurrently expanding to support these new and expanding hospital programs that include a new, state-of-the art Lab Medicine building with dedicated laboratory space for individual areas.
Candidates must have an MD and/or PhD with expertise in cellular immunology including flow cytometry and functional/cytotoxic assays, particularly as they apply to the analysis of hematopoietic stem cell transplantation, immune reconstitution and immune modulation. Candidates must also have expertise in innate and humoral immunity, particularly related to clinical test utilization and assay development. Board Certification from the American Board of Clinical Laboratory Immunology is preferred and Board Certification from the American Board of Histocompatibility and Immunogenetics would be a plus. An additional requirement is the ability to obtain a NYS DOH COQ covering the relevant categories.
Applicants should send CV and cover letter describing personal area(s) of interest and long-term career goals to:
Melissa S Pessin, MD PhDChair, Department of Laboratory MedicineMemorial Sloan Kettering Cancer CenterCenter for Laboratory Medicine327 East 64th Street, Fifth Floor, Room 542New York, NY 10065email: email@example.com
Tel: +1 414 271 2456 | Fax: +1 414 276 3349 | Email: firstname.lastname@example.org