Papers in this category present clinical research that has a clear potential to optimize patient care, with particular emphasis on high quality randomized controlled trials, novel combination treatments, therapies, novel diagnostic or prognostic insights and new insights into mechanism of action.
Bryan D. Choi, md, phd
Massachusetts General Hospital
"CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma"
Bryan D. Choi, Xiaoling Yu, Ana P. Castano, Henia Darr, Daniel B. Henderson,
Amanda A. Bouffard, Rebecca C. Larson, Irene Scarfò, Stefanie R. Bailey,
Genevieve M. Gerhard, Matthew J. Frigault, Mark B. Leick, Andrea Schmidts,
Jason G. Sagert, William T. Curry, Bob S. Carter and Marcela V. Maus
Journal for ImmunoTherapy of Cancer 2019, 7:302 (14 November 2019)